Article
Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2005
Raffai Robert L, Loeb Samuel M, Weisgraber Karl H
Abstract excerpt
OBJECTIVE: The mechanisms by which apolipoprotein E (apoE) can promote the regression of atherosclerosis are not well understood. This study examined whether apoE can promote atherosclerosis regression independently of lowering plasma cholesterol levels. METHODS AND RESULTS: We studied hypomorphic apoE mice (Apoe(h/h)), which express an apoE4-like form of mouse apoE at approximately 2% to 5% of normal levels in...
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