Article
Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2001
Moghadasian M H, McManus B M, Nguyen L B, Shefer S, Nadji M, Godin D V, Green T J, Hill J, Yang Y, Scudamore C H, Frohlich J J
Abstract excerpt
Apolipoprotein E (apo E) deficiency (or its abnormalities in humans) is associated with a series of pathological conditions including dyslipidemia, atherosclerosis, Alzheimer's disease, and shorter life span. The purpose of this study was to characterize these conditions in apo E-deficient C57BL/6J mice and relate them to human disorders. Deletion of apo E gene in mice is associated with changes in lipoprotein...
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