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Article

Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2012

Eberlé Delphine, Kim Roy Y, Luk Fu Sang, de Mochel Nabora Soledad Reyes, Gaudreault Nathalie, Olivas Victor R, Kumar Nikit, Posada Jessica M, Birkeland Andrew C, Rapp Joseph H, Raffai Robert L

Abstract excerpt

OBJECTIVE: Apolipoprotein (apo) E4 is an established risk factor for atherosclerosis, but the structural components underlying this association remain unclear. ApoE4 is characterized by 2 biophysical properties: domain interaction and molten globule state. Substituting Arg-61 for Thr-61 in mouse apoE introduces domain interaction without molten globule state, allowing us to delineate potential proatherogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, Atherogenic

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Share to Macrophages, Peritoneal

Share to Mice, Inbred C57BL

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Source

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Identifiers

PMID: 22441102
DOI: 10.1161/ATVBAHA.112.246389
PMCID: PMC3346714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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