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Article

Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.

Eukaryotic cell - 1 Dec 2004

Pathak Ritu, Bogomolnaya Lydia M, Guo Jinbai, Polymenis Michael

Abstract excerpt

How cells determine when to initiate DNA replication is poorly understood. Here we report that in Saccharomyces cerevisiae overexpression of the dosage-dependent cell cycle regulator genes DCR2 (YLR361C) and GID8 (DCR1/YMR135C) accelerates initiation of DNA replication. Cells lacking both GID8 and DCR2 delay initiation of DNA replication. Genetic analysis suggests that Gid8p functions upstream of Dcr2p to promote...

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Source

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Identifiers

PMID: 15590836
DOI: 10.1128/EC.3.6.1627-1638.2004
PMCID: PMC539013

Genes

GID8
CLN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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