Article
CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast.
Molecular biology of the cell - 15 Jul 2011
Fukuura Masayoshi, Nagao Koji, Obuse Chikashi, Takahashi Tatsuro S, Nakagawa Takuro, Masukata Hisao
Abstract excerpt
Cyclin-dependent kinase (CDK) plays essential roles in the initiation of DNA replication in eukaryotes. Although interactions of CDK-phosphorylated Sld2/Drc1 and Sld3 with Dpb11 have been shown to be essential in budding yeast, it is not known whether the mechanism is conserved. In this study, we investigated how CDK promotes the assembly of replication proteins onto replication origins in fission yeast....
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