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Article

The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle.

Cell - 5 Apr 1996

Heichman K A, Roberts J M

Abstract excerpt

CDC16 and CDC27 were identified as genes in S. cerevisiae necessary to limit DNA replication to once per cell cycle. A screen for mutants that overreplicated their DNA uncovered new conditional alleles that cause accumulation of up to 8C DNA. DNA overreplication involves all chromosomes and does not require passage through mitosis or another START. It occurs within a single cell cycle and can cause arrest at the...

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Source

Identifiers

PMID: 8620535
DOI: 10.1016/s0092-8674(00)81080-6

Genes

CDC16
CDC27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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