The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle.

doi:10.1016/s0092-8674(00)81080-6

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Article

The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle.

Cell - 5 Apr 1996

Heichman K A, Roberts J M

Abstract excerpt

CDC16 and CDC27 were identified as genes in S. cerevisiae necessary to limit DNA replication to once per cell cycle. A screen for mutants that overreplicated their DNA uncovered new conditional alleles that cause accumulation of up to 8C DNA. DNA overreplication involves all chromosomes and does...

Topics

Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome
Apc6 Subunit, Anaphase-Promoting Complex-Cyclosome
CDC2 Protein Kinase
CDC28 Protein Kinase, S cerevisiae
Cell Count
Cell Cycle
Cell Cycle Proteins
DNA Replication
DNA, Fungal
Electrophoresis, Gel, Pulsed-Field
G2 Phase
Genes, Fungal
Mitosis
Mutation
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Temperature
Ubiquitin-Protein Ligases

Source

Open in PubMed

Identifiers

PMID: 8620535
DOI: 10.1016/s0092-8674(00)81080-6

Genes

CDC16
CDC27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8620535-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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