Article
Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations.
Cancer research - 1 Apr 2007
Wang Yun, Woodgate Roger, McManus Terrence P, Mead Samantha, McCormick J Justin, Maher Veronica M
Abstract excerpt
Xeroderma pigmentosum variant (XPV) patients have normal DNA excision repair, yet are predisposed to develop sunlight-induced cancer. They exhibit a 25-fold higher than normal frequency of UV-induced mutations and very unusual kinds (spectrum), mainly transversions. The primary defect in XPV cell...
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