Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells.

Abstract excerpt

Replication of UV-induced photoproducts requires the activity of specific DNA polymerases. The DNA polymerase eta, the absence of which gives rise to the cancer-prone xeroderma pigmentosum variant syndrome, is one of these translesion DNA polymerases. Other error-prone DNA polymerases are present in human cells and may contribute to the UV-induced mutation spectrum.

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