Uncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells.

doi:10.1002/mc.70028

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Uncovering the Role of DNA Repair Impairment in UVA-Induced Mutagenesis in Human Xeroderma Pigmentosum Variant Cells.

Molecular carcinogenesis - 1 Nov 2025

Corradi Camila, Moreno Natália Cestari, Quintero-Ruiz Nathalia, Silva Leandro Giovana da, Teatin Latancia Marcela, de Souza Tiago Antonio, Munford Veridiana, Menck Carlos Frederico Martins

Abstract excerpt

Ultraviolet A (UVA) radiation induces DNA damage both directly, by forming cyclobutane pyrimidine dimers (CPDs), and indirectly, by generating oxidative stress. Cells rely on nucleotide excision repair (NER) and translesion synthesis (TLS) to tolerate these lesions. Xeroderma pigmentosum variant (XP-V) cells, deficient in DNA polymerase eta (pol eta), exhibit a heightened risk of skin cancer due to impaired TLS....

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Topics

Humans
Ultraviolet Rays
DNA Repair
Xeroderma Pigmentosum
Mutagenesis
DNA Damage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pyrimidine Dimers

Oxidative Stress

Mutation

DNA-Directed DNA Polymerase

Exome Sequencing

Acetylcysteine

Skin Neoplasms

Y-Family DNA Polymerases

Source

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Identifiers

PMID: 40794023
DOI: 10.1002/mc.70028
PMCID: PMC12535409

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