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Article

The role of DNA polymerase iota in UV mutational spectra.

Mutation research - 25 Jul 2006

Choi Jun-Hyuk, Besaratinia Ahmad, Lee Dong-Hyun, Lee Chong-Soon, Pfeifer Gerd P

Abstract excerpt

UVB (280-320 nm) and UVC (200-280 nm) irradiation generate predominantly cyclobutane pyrimidine dimers (CPDs) and (6-4) photoproducts in DNA. CPDs are thought to be responsible for most of the UV-induced mutations. Thymine-thymine CPDs, and probably also CPDs containing cytosine, are replicated in vivo in a largely accurate manner by a DNA polymerase eta (Pol eta) dependent process. Pol eta is a DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16472831
DOI: 10.1016/j.mrfmmm.2006.01.003

Genes

POLH
POLI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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