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Article

PTPRC (CD45) variation and disease association studied using single nucleotide polymorphism tagging.

Tissue antigens - 1 May 2008

Hennig B J, Fry A E, Hirai K, Tahara H, Tamori A, Moller M, Hopkin J, Hill A V, Bodmer W, Beverley P, Tchilian E

Abstract excerpt

CD45 is a haemopoietic tyrosine phosphatase, crucial for lymphocyte signalling. Two polymorphisms (C77G and A138G), which alter CD45 isoform expression, are associated with autoimmune and infectious diseases. Using HapMap data, we show that there is substantial linkage disequilibrium across the CD45 gene (PTPRC), with similar patterns in different populations. Employing a set of single nucleotide polymorphisms,...

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Source

Identifiers

PMID: 18312479
DOI: 10.1111/j.1399-0039.2008.01014.x

Genes

PTPRC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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