Article
p53 polymorphisms associated with mutations in and loss of heterozygosity of the p53 gene in male oral squamous cell carcinomas in Taiwan.
British journal of cancer - 17 Jan 2005
Hsieh L-L, Huang T-H, Chen I-H, Liao C-T, Wang H-M, Lai C-H, Liou S-H, Chang J T-C, Cheng A-J
Abstract excerpt
The present study was designed to examine whether different p53 haplotypes of exon 4-intron 3-intron 6 affect the frequency of mutations and loss of heterozygosity (LOH) of the p53 gene in male oral squamous cell carcinomas (OSCCs) in Taiwan. We found that individuals without two Pro-W-G alleles had significantly higher frequency of p53 mutations than those with two Pro-W-G alleles (odds ratio (OR) = 1.98; 95%...
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