Article
A novel polymorphism in intron 6 of the human p53 gene: a possible association with cancer predisposition and susceptibility.
DNA and cell biology - 1 Dec 1995
Peller S, Kopilova Y, Slutzki S, Halevy A, Kvitko K, Rotter V
Abstract excerpt
We present a novel polymorphic 8-bp sequence in intron 6 of the p53 gene that maps between bp 55 and 62 of the 3' end of exon 6. Of normal blood samples, 32% were heterozygotic for this polymorphism and display a NN' genotype, whereas 68% of the population is homozygotic for the N genotype. The r...
Topics
- Base Sequence
- Breast Neoplasms
- Chromosome Deletion
- DNA Primers
- Gastrointestinal Neoplasms
- Genes, p53
- Genetic Predisposition to Disease
- Heterozygote
- Humans
- Introns
- Leukemia, Lymphocytic, Chronic, B-Cell
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic