Article
Characteristics of mutations in the p53 gene in oral squamous cell carcinoma associated with betel quid chewing and cigarette smoking in Taiwanese.
Carcinogenesis - 1 Sept 2001
Hsieh L L, Wang P F, Chen I H, Liao C T, Wang H M, Chen M C, Chang J T, Cheng A J
Abstract excerpt
p53 mutations are etiologically associated with the development of oral squamous cell carcinomas (OSCCs) or are associated with exposure to specific carcinogens. In this study, we used PCR-single strand conformation polymorphism and DNA sequencing to analyze the conserved regions of the p53 gene (exons 5-9) in OSCC tumor specimens from 187 patients with varied histories of betel quid, tobacco and alcohol use....
Topics
- Adult
- Aged
- Areca
- Carcinoma, Squamous Cell
- Conserved Sequence
- Exons
- Female
- Genes, p53
- Humans
- Male
- Middle Aged
- Mouth Neoplasms
- Mutation
- Neoplasm Staging