TP53 single nucleotide polymorphism rs1042522 in salivary gland neoplasms.

doi:10.1002/hed.23513

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Article

TP53 single nucleotide polymorphism rs1042522 in salivary gland neoplasms.

Head & neck - 1 Dec 2014

Gomes Carolina C, Fonseca-Silva Thiago, Diniz Marina G, Orsine Lissur A, Gomez Ricardo S

Abstract excerpt

BACKGROUND: The TP53 single nucleotide polymorphism (SNP) rs1042522 encodes arginine (Arg) or proline (Pro). The Arg variant is more effective at inducing apoptosis than the Pro. METHODS: We assessed this SNP through direct sequencing of benign and malignant salivary neoplasms of Brazilian patients and compared the results with healthy controls' data. BAX, BCL-2, and CASPASE-3 mRNA levels were assessed by...

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PMID: 24115240
DOI: 10.1002/hed.23513

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