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Article

Essential role of the small GTPase Ran in postnatal pancreatic islet development.

PloS one - 1 Jan 2011

Xia Fang, Dohi Takehiko, Martin Nina M, Raskett Christopher M, Liu Qin, Altieri Dario C

Abstract excerpt

The small GTPase Ran orchestrates pleiotropic cellular responses of nucleo-cytoplasmic shuttling, mitosis and subcellular trafficking, but whether deregulation of these pathways contributes to disease pathogenesis has remained elusive. Here, we generated transgenic mice expressing wild type (WT) Ran, loss-of-function Ran T24N mutant or constitutively active Ran G19V mutant in pancreatic islet β cells under the...

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Identifiers

PMID: 22114719
DOI: 10.1371/journal.pone.0027879
PMCID: PMC3219697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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