Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The gastrin receptor promotes pancreatic growth in transgenic mice.

Pancreas - 1 Mar 2002

Yen Tina W F, Sandgren Eric P, Liggitt H Denny, Palmiter Richard D, Zhou Weigong, Hinds Thomas R, Grippo Paul J, McDonald Jerome M, Robinson Linda M, Bell Richard H

Abstract excerpt

INTRODUCTION: We demonstrated previously, in two different rodent models of pancreatic cancer, that the gastrin receptor is present on malignant pancreatic tumors in spite of the fact that the normal adult rat and mouse pancreas does not express gastrin receptors. AIMS AND METHODOLOGY: To determine whether gastrin receptors mediate pancreatic growth or promote carcinogenesis or both, we created a transgenic mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Calcium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrins

Share to Iodine Radioisotopes

Share to Mice, Transgenic

Share to Pancreas

Share to Pancreatic Neoplasms

Source

Identifiers

PMID: 11854616
DOI: 10.1097/00006676-200203000-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The gastrin receptor promotes pancreatic growth in transgenic mice.PMID 11854616Read ↗

Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.Semantic proximity Read ↗

Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia.Semantic proximity Read ↗

Role of CCK-A receptor for pancreatic function in mice: a study in CCK-A receptor knockout mice.Semantic proximity Read ↗

Expression of a dominant-negative mutant TGF-beta type II receptor in transgenic mice reveals essential roles for TGF-beta in regulation of growth and differentiation in the exocrine pancreas.Semantic proximity Read ↗

Impaired growth of pancreatic exocrine cells in transgenic mice expressing human activin betaE subunit.Semantic proximity Read ↗

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.Semantic proximity Read ↗

Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.Semantic proximity Read ↗

Characterization of the CCK-C (cancer) receptor in human pancreatic cancerSemantic proximity Read ↗

Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation.Semantic proximity Read ↗

Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in miceSemantic proximity Read ↗

Glucagon gene 5'-flanking sequences direct expression of simian virus 40 large T antigen to the intestine, producing carcinoma of the large bowel in transgenic mice.Semantic proximity Read ↗

Characterisation of a transgenic mouse expressing R122H human cationic trypsinogen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.