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Permanent neonatal diabetes in INS(C94Y) transgenic pigs.

Diabetes - 1 May 2013

Renner Simone, Braun-Reichhart Christina, Blutke Andreas, Herbach Nadja, Emrich Daniela, Streckel Elisabeth, Wünsch Annegret, Kessler Barbara, Kurome Mayuko, Bähr Andrea, Klymiuk Nikolai, Krebs Stefan, Puk Oliver, Nagashima Hiroshi, Graw Jochen, Blum Helmut, Wanke Ruediger, Wolf Eckhard

Abstract excerpt

Mutations in the insulin (INS) gene may cause permanent neonatal diabetes mellitus (PNDM). Ins2 mutant mouse models provided important insights into the disease mechanisms of PNDM but have limitations for translational research. To establish a large animal model of PNDM, we generated INS(C94Y) transgenic pigs. A line expressing high levels of INS(C94Y) mRNA (70-86% of wild-type INS transcripts) exhibited elevated...

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Identifiers

PMID: 23274907
DOI: 10.2337/db12-1065
PMCID: PMC3636654

Genes

INS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Permanent neonatal diabetes in INS(C94Y) transgenic pigs.PMID 23274907Read ↗

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