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Article

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.

American journal of physiology. Endocrinology and metabolism - 15 Nov 2014

Kahraman Sevim, Dirice Ercument, De Jesus Dario F, Hu Jiang, Kulkarni Rohit N

Abstract excerpt

Studies in both humans and rodents suggest that maternal diabetes leads to a higher risk of the fetus developing impaired glucose tolerance and obesity during adulthood. However, the impact of hyperinsulinemia in the mother on glucose homeostasis in the offspring has not been fully explored. We aimed to determine the consequences of maternal insulin resistance on offspring metabolism and endocrine pancreas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25249504
DOI: 10.1152/ajpendo.00210.2014
PMCID: PMC4233258

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