dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.

doi:10.1016/j.ydbio.2004.08.044

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Article

dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.

Developmental biology - 15 Dec 2004

Conder Ryan, Yu Hong, Ricos Michael, Hing Huey, Chia William, Lim Louis, Harden Nicholas

Abstract excerpt

The Pak kinases are effectors for the small GTPases Rac and Cdc42 and are divided into two subfamilies. Group I Paks possess an autoinhibitory domain that can suppress their kinase activity in trans. In Drosophila, two Group I kinases have been identified, dPak and Pak3. Rac and Cdc42 participate in dorsal closure of the embryo, a process in which a hole in the dorsal epidermis is sealed through migration of the...

Topics

Amino Acid Sequence
Animals
Cell Shape
Cytoskeleton
Drosophila Proteins
Drosophila melanogaster
Epidermal Cells
Epidermis
Female
Humans
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

JNK Mitogen-Activated Protein Kinases

MAP Kinase Signaling System

Male

Molecular Sequence Data

Morphogenesis

Phenotype

Phosphotyrosine

Source

Open in PubMed

Identifiers

PMID: 15581872
DOI: 10.1016/j.ydbio.2004.08.044

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dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.PMID 15581872Read ↗

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