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Article

Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.

Mechanisms of development - 1 Jan 2000

Fernández Beatriz García, Arias Alfonso Martinez, Jacinto Antonio

Abstract excerpt

During the final stages of embryogenesis, the Drosophila embryo exhibits a dorsal hole covered by a simple epithelium of large cells termed the amnioserosa (AS). Dorsal closure is the process whereby this hole is closed through the coordination of cellular activities within both the AS and the epidermis. Genetic analysis has shown that signalling through Jun N-terminal Kinase (JNK) and Decapentaplegic (Dpp), a...

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Identifiers

PMID: 17950580
DOI: 10.1016/j.mod.2007.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.PMID 17950580Read ↗

Specialized extraembryonic cells connect embryonic and extraembryonic epidermis in response to Dpp during dorsal closure in Drosophila.Semantic proximity Read ↗

Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure.Semantic proximity Read ↗

Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo.Semantic proximity Read ↗

Amnioserosa is required for dorsal closure in Drosophila.Semantic proximity Read ↗

Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.Semantic proximity Read ↗

Sec61alpha is required for dorsal closure during Drosophila embryogenesis through its regulation of Dpp signaling.Semantic proximity Read ↗

dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.Semantic proximity Read ↗

Modulation of morphogenesis by Egfr during dorsal closure in Drosophila.Semantic proximity Read ↗

The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila.Semantic proximity Read ↗

Planar polarity and actin dynamics in the epidermis of Drosophila.Semantic proximity Read ↗

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.Semantic proximity Read ↗

Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade.Semantic proximity Read ↗

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