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Article

Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.

PLoS genetics - 1 Feb 2017

Rousset Raphaël, Carballès Fabrice, Parassol Nadège, Schaub Sébastien, Cérézo Delphine, Noselli Stéphane

Abstract excerpt

Tissue morphogenesis relies on proper differentiation of morphogenetic domains, adopting specific cell behaviours. Yet, how signalling pathways interact to determine and coordinate these domains remains poorly understood. Dorsal closure (DC) of the Drosophila embryo represents a powerful model to study epithelial cell sheet sealing. In this process, JNK (JUN N-terminal Kinase) signalling controls leading edge...

Topics

Animals
Body Patterning
Cell Differentiation
Drosophila melanogaster
Ectoderm
Embryo, Nonmammalian
Embryonic Development
Epithelial Cells
Gene Expression Regulation, Developmental
JNK Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MAP Kinase Signaling System

Morphogenesis

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 28231245
DOI: 10.1371/journal.pgen.1006640
PMCID: PMC5344535

Genes

JUN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.PMID 28231245Read ↗

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Thorax closure in Drosophila: involvement of Fos and the JNK pathway.Semantic proximity Read ↗

Dpp signalling orchestrates dorsal closure by regulating cell shape changes both in the amnioserosa and in the epidermis.Semantic proximity Read ↗

JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.Semantic proximity Read ↗

Invasive cell behavior during Drosophila imaginal disc eversion is mediated by the JNK signaling cascade.Semantic proximity Read ↗

The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis.Semantic proximity Read ↗

dPak is required for integrity of the leading edge cytoskeleton during Drosophila dorsal closure but does not signal through the JNK cascade.Semantic proximity Read ↗

Cabut, a C2H2 zinc finger transcription factor, is required during Drosophila dorsal closure downstream of JNK signaling.Semantic proximity Read ↗

Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing.Semantic proximity Read ↗

Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Semantic proximity Read ↗

Investigation of leading edge formation at the interface of amnioserosa and dorsal ectoderm in the Drosophila embryo.Semantic proximity Read ↗

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