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Article

The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila.

Current biology : CB - 28 Oct 2003

Wei Ho-Chun, Sanny Justina, Shu Huidy, Baillie David L, Brill Julie A, Price James V, Harden Nicholas

Abstract excerpt

The Sac1 lipid phosphatase dephosphorylates several phosphatidylinositol (PtdIns) phosphates and, in yeast, regulates a diverse range of cellular processes including organization of the actin cytoskeleton and secretion. We have identified mutations in the gene encoding Drosophila Sac1. sac1 mutants die as embryos with defects in dorsal closure (DC). DC involves the migration of the epidermis to close a hole in...

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PMID: 14588244
DOI: 10.1016/j.cub.2003.09.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila.PMID 14588244Read ↗

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