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Article

Formation of proximal and anterior limb skeleton requires early function of Irx3 and Irx5 and is negatively regulated by Shh signaling.

Developmental cell - 28 Apr 2014

Li Danyi, Sakuma Rui, Vakili Niki A, Mo Rong, Puviindran Vijitha, Deimling Steven, Zhang Xiaoyun, Hopyan Sevan, Hui Chi-chung

Abstract excerpt

Limb skeletal pattern relies heavily on graded Sonic hedgehog (Shh) signaling. As a morphogen and growth cue, Shh regulates identities of posterior limb elements, including the ulna/fibula and digits 2 through 5. In contrast, proximal and anterior structures, including the humerus/femur, radius/tibia, and digit 1, are regarded as Shh independent, and mechanisms governing their specification are unclear. Here, we...

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PMID: 24726282
DOI: 10.1016/j.devcel.2014.03.001

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