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Article

BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development.

PloS one - 1 Jan 2013

Vieux-Rochas Maxence, Bouhali Kamal, Mantero Stefano, Garaffo Giulia, Provero Paolo, Astigiano Simonetta, Barbieri Ottavia, Caratozzolo Mariano F, Tullo Apollonia, Guerrini Luisa, Lallemand Yvan, Robert Benoît, Levi Giovanni, Merlo Giorgio R

Abstract excerpt

The Dlx and Msx homeodomain transcription factors play important roles in the control of limb development. The combined disruption of Msx1 and Msx2, as well as that of Dlx5 and Dlx6, lead to limb patterning defects with anomalies in digit number and shape. Msx1;Msx2 double mutants are characterized by the loss of derivatives of the anterior limb mesoderm which is not observed in either of the simple mutants....

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Identifiers

PMID: 23382810
DOI: 10.1371/journal.pone.0051700
PMCID: PMC3558506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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