Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Function of BMPs in the apical ectoderm of the developing mouse limb.

Developmental biology - 1 May 2004

Wang Chi-Kuang Leo, Omi Minoru, Ferrari Deborah, Cheng Hsu-Chen, Lizarraga Gail, Chin Hsian-Jean, Upholt William B, Dealy Caroline N, Kosher Robert A

Abstract excerpt

Several bone morphogenetic proteins (BMPs) are expressed in the apical ectodermal ridge (AER), a critical signaling center that directs the outgrowth and patterning of limb mesoderm, but little is known about their function. To study the functions of apical ectodermal BMPs, an AER-specific promoter element from the Msx2 gene was used to target expression of the potent BMP antagonist noggin to the apical ectoderm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Morphogenetic Proteins
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Ectoderm

Share to Extremities

Share to Homeodomain Proteins

Share to Limb Deformities, Congenital

Share to Proteins

Source

Identifiers

PMID: 15081361
DOI: 10.1016/j.ydbio.2004.01.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Function of BMPs in the apical ectoderm of the developing mouse limb.PMID 15081361Read ↗

Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.Semantic proximity Read ↗

Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development.Semantic proximity Read ↗

Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.Semantic proximity Read ↗

Constitutive activation of ectodermal β-catenin induces ectopic outgrowths at various positions in mouse embryo and affects abdominal ventral body wall closure.Semantic proximity Read ↗

BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development.Semantic proximity Read ↗

FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis.Semantic proximity Read ↗

Multiple roles of mesenchymal beta-catenin during murine limb patterning.Semantic proximity Read ↗

Dual Bmp-negative feedback loops modulate both AER and ZPA function to buffer and constrain postaxial digit numberSemantic proximity Read ↗

Targeted misexpression of constitutively active BMP receptor-IB causes bifurcation, duplication, and posterior transformation of digit in mouse limb.Semantic proximity Read ↗

The apical ectodermal ridge is a timer for generating distal limb progenitors.Semantic proximity Read ↗

Functions of FGF signalling from the apical ectodermal ridge in limb development.Semantic proximity Read ↗

Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.