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Article

Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy.

PloS one - 1 Jan 2013

Preissner Sarah C, Hoffmann Michael F, Preissner Robert, Dunkel Mathias, Gewiess Andreas, Preissner Saskia

Abstract excerpt

The cytochrome P450 (CYP) enzymes are major players in drug metabolism. More than 2,000 mutations have been described, and certain single nucleotide polymorphisms (SNPs) have been shown to have a large impact on CYP activity. Therefore, CYPs play an important role in inter-individual drug response and their genetic variability should be factored into personalized medicine. To identify the most relevant...

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Identifiers

PMID: 24340040
DOI: 10.1371/journal.pone.0082562
PMCID: PMC3858335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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