Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytochrome P450 pharmacogenetics in African populations.

Drug metabolism reviews - 1 May 2013

Alessandrini Marco, Asfaha Sahle, Dodgen Tyren Mark, Warnich Louise, Pepper Michael Sean

Abstract excerpt

The Cytochrome P450 (CYP450) family of enzymes is involved in the oxidative metabolism of many therapeutic drugs, carcinogens and various endogenous substrates. These enzymes are highly polymorphic at an inter-individual and inter-ethnic level. Polymorphisms or genetic variations account for up to 30% of inter-individual differences seen in a variety of drug responses. The frequencies of the different metabolizer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Black People
Share to Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Genotype

Share to Pharmacogenetics

Share to Pharmacogenetics and Drug Metabolism

Share to Phenotype

Source

Identifiers

PMID: 23590174
DOI: 10.3109/03602532.2013.783062

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytochrome P450 pharmacogenetics in African populations.PMID 23590174Read ↗

African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug DevelopmentSemantic proximity Read ↗

African variation at Cytochrome P450 genesSemantic proximity Read ↗

Genetic polymorphism of drug metabolising enzymes in African populations: implications for the use of neuroleptics and antidepressants.Semantic proximity Read ↗

Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles.Semantic proximity Read ↗

Drug Metabolizing Enzymes: An Exclusive Guide into Latest Research in Pharmaco-genetic Dynamics in Arab CountriesSemantic proximity Read ↗

Cytochrome P450 Drug Metabolizing Enzymes in Roma Population Samples: Systematic Review of the Literature.Semantic proximity Read ↗

Cytochrome P450 variations in different ethnic populations.Semantic proximity Read ↗

Cytochrome P450 in Pharmacogenetics: An Update.Semantic proximity Read ↗

The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.Semantic proximity Read ↗

Meta-analysis of the global distribution of clinically relevant CYP2C8 alleles and their inferred functional consequences.Semantic proximity Read ↗

Novel variants of major drug-metabolising enzyme genes in diverse African populations and their predicted functional effects.Semantic proximity Read ↗

CYP2C gene polymorphisms in North African populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.