Article
The Ipl1/Aurora kinase family: methods of inhibition and functional analysis in mammalian cells.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2005
Ditchfield Claire, Keen Nicholas, Taylor Stephen S
Abstract excerpt
The Ipl1/Aurora family of protein kinases are required for accurate chromosome segregation. Because members of this family are often overexpressed in human tumors, they have recently received much attention, both from the academic community and the pharmaceutical industry. Indeed, two small molecule Aurora kinase inhibitors have recently been described. In this chapter, we describe several methods for...
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