RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways.

doi:10.1096/fj.04-1900com

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Article

RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2004

Rong Ling Ling, Yan Shi-Fang, Wendt Thoralf, Hans Diana, Pachydaki Sophia, Bucciarelli Loredana G, Adebayo Adebukola, Qu Wu, Lu Yan, Kostov Konstantin, Lalla Evanthia, Yan Shi Du, Gooch Clifton, Szabolcs Matthias, Trojaborg Werner, Hays Arthur P, Schmidt Ann Marie

Abstract excerpt

Axotomy of peripheral nerve stimulates events in multiple cell types that initiate a limited inflammatory response to axonal degeneration and simultaneous outgrowth of neurites into the distal segments after injury. We found that pharmacological blockade of RAGE impaired peripheral nerve regeneration in mice subjected to RAGE blockade and acute crush of the sciatic nerve. As our studies revealed that RAGE was...

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PMID: 15576485
DOI: 10.1096/fj.04-1900com

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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