Article
An intact intermediate filament network is required for collateral sprouting of small diameter nerve fibers.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Oct 2003
Belecky-Adams Teri, Holmes Michael, Shan Yuqing, Tedesco C Susan, Mascari Carla, Kaul Ajay, Wight David C, Morris Randal E, Sussman Mark, Diamond Jack, Parysek Linda M
Abstract excerpt
Expression of the intermediate filament (IF) protein peripherin is initiated during development at the time of axonal extension and increases during regeneration of nerve fibers. To test whether the IF network is essential for neuron process outgrowth in the mature organism in vivo, we disrupted endogenous peripherin IF in small-sized dorsal root ganglion (DRG) neurons in transgenic mice via expression of a...
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