Article
Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments.
Experimental neurology - 1 Nov 1997
Zhu Q, Couillard-Després S, Julien J P
Abstract excerpt
Using the technique of homologous recombination in embryonic stem cells, we generated mice bearing a targeted disruption of the gene encoding the neurofilament light (NF-L) protein. The absence of NF-L protein in mice resulted in dramatic declines of approximately 20-fold in the levels of neurofilament medium and heavy proteins in the brain and sciatic nerve while increases were detected for other cytoskeletal...
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