Fcγ receptor-mediated inflammation inhibits axon regeneration.

doi:10.1371/journal.pone.0088703

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Article

Fcγ receptor-mediated inflammation inhibits axon regeneration.

PloS one - 1 Jan 2014

Zhang Gang, Bogdanova Nataliia, Gao Tong, Song Julia J, Cragg Mark S, Glennie Martin J, Sheikh Kazim A

Abstract excerpt

Anti-glycan/ganglioside antibodies are the most common immune effectors found in patients with Guillain-Barré Syndrome, which is a peripheral autoimmune neuropathy. We previously reported that disease-relevant anti-glycan autoantibodies inhibited axon regeneration, which echo the clinical association of these antibodies and poor recovery in Guillain-Barré Syndrome. However, the specific molecular and cellular...

Topics

Animals
Autoantibodies
Axons
Behavior, Animal
Complement Activation
Disease Models, Animal
Gangliosides
Guillain-Barre Syndrome
Inflammation
Macrophages
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Transgenic

Mutation

Nerve Regeneration

Peripheral Nerves

Receptors, IgG

Sciatic Nerve

Source

Open in PubMed Open full text

Identifiers

PMID: 24523933
DOI: 10.1371/journal.pone.0088703
PMCID: PMC3921223

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