Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect.

Abstract excerpt

Schwann cell-axon interactions in the development, maintenance, and regeneration of the normal peripheral nervous system are complex. A previously described transgene-induced insertional mutation (BPFD#36), now referred to as Enervated (Enr), results in disrupted Schwann cell-axon interactions. In this report, after a crush or transection injury to Enr peripheral nerves, we demonstrate impaired nerve...

Topics

• Animals
• Gene Expression
• Homozygote
• Mice
• Mice, Transgenic
• Microscopy, Electron
• Mutation
• Nerve Crush
• Nerve Regeneration
• Nerve Tissue
• Peripheral Nerves