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Article

Axonal neuregulin 1 is a rate limiting but not essential factor for nerve remyelination.

Brain : a journal of neurology - 1 Jul 2013

Fricker Florence R, Antunes-Martins Ana, Galino Jorge, Paramsothy Remi, La Russa Federica, Perkins James, Goldberg Rebecca, Brelstaff Jack, Zhu Ning, McMahon Stephen B, Orengo Christine, Garratt Alistair N, Birchmeier Carmen, Bennett David L H

Abstract excerpt

Neuregulin 1 acts as an axonal signal that regulates multiple aspects of Schwann cell development including the survival and migration of Schwann cell precursors, the ensheathment of axons and subsequent elaboration of the myelin sheath. To examine the role of this factor in remyelination and repair following nerve injury, we ablated neuregulin 1 in the adult nervous system using a tamoxifen inducible Cre...

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Identifiers

PMID: 23801741
DOI: 10.1093/brain/awt148
PMCID: PMC3692042

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Source receipt: pubmed, retrieved 7 Sept 2026.

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