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Article

Impairment of toll-like receptors 2 and 4 leads to compensatory mechanisms after sciatic nerve axotomy.

Journal of neuroinflammation - 24 May 2016

Freria C M, Bernardes D, Almeida G L, Simões G F, Barbosa G O, Oliveira A L R

Abstract excerpt

BACKGROUND: Peripheral nerve injury results in retrograde cell body-related changes in the spinal motoneurons that will contribute to the regenerative response of their axons. Successful functional recovery also depends on molecular events mediated by innate immune response during Wallerian degeneration in the nerve microenvironment. A previous study in our lab demonstrated that TLR 2 and 4 develop opposite...

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Source

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Identifiers

PMID: 27222120
DOI: 10.1186/s12974-016-0579-6
PMCID: PMC4879730

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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