Structural alterations of the epidermal growth factor receptor gene in human gliomas.

doi:10.1073/pnas.89.7.2965

Article

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1 Apr 1992

Abstract excerpt

The epidermal growth factor receptor (EGFR) gene is amplified in 40% of malignant gliomas, and the amplified genes are frequently rearranged. We have characterized the genetic alterations associated with these rearrangements in five malignant gliomas. In one tumor the rearrangement resulted in the deletion of most of the extracytoplasmic domain of the receptor, resulting in a hybrid mRNA between new sequences and...

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