Article
Amplified cellular oncogenes in neoplasms of the human central nervous system.
Mutation research - 1 May 1992
Fuller G N, Bigner S H
Abstract excerpt
Significant advances have recently been made in a number of areas concerning central nervous system (CNS) neoplasia. Particularly salient are the following: (1) gene amplification is related to increasing grade of human glioma malignancy and occurs in approximately 40% of the most common and most malignant variety of glioma, glioblastoma multiforme (GBM), (2) by far the most commonly amplified gene in...
Topics
- Adult
- Amino Acid Sequence
- Brain Neoplasms
- Child
- ErbB Receptors
- Gene Amplification
- Genes, myc
- Glioma
- Humans
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases