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Article

A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors.

Japanese journal of cancer research : Gann - 1 Aug 1990

Yamazaki H, Ohba Y, Tamaoki N, Shibuya M

Abstract excerpt

Two transplantable cell lines of human glioblastoma multiforme GL-3 and GL-5 carried an amplification and overexpression of structurally altered epidermal growth factor (EGF) receptor gene: the 140 kilodalton EGF receptors in these cases exhibited a constitutively expressed tyrosine kinase activi...

Topics

Animals
Base Sequence
Brain Neoplasms
Cell Transformation, Neoplastic
Chromosome Deletion
DNA, Neoplasm
ErbB Receptors
Gene Expression Regulation, Neoplastic
Gene Library
Glioblastoma
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Recombination, Genetic

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2168866
DOI: 10.1111/j.1349-7006.1990.tb02644.x
PMCID: PMC5918101

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2168866-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors.PMID 2168866Read ↗

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