Article
Bradykinin-induced p42/p44 MAPK phosphorylation and cell proliferation via Src, EGF receptors, and PI3-K/Akt in vascular smooth muscle cells.
Journal of cellular physiology - 1 Jun 2005
Yang Chuen-Mao, Lin Meng-I, Hsieh Hsi-Lung, Sun Chi-Chin, Ma Yunn-Hwa, Hsiao Li-Der
Abstract excerpt
In our previous study, bradykinin (BK) exerts its mitogenic effect through Ras/Raf/MEK/MAPK pathway in vascular smooth muscle cells (VSMCs). In addition to this pathway, the non-receptor tyrosine kinases (Src), EGF receptor (EGFR), and phosphatidylinositol 3-kinase (PI3-K) have been implicated in linking a variety of G-protein coupled receptors to MAPK cascades. Here, we investigated whether these different...
Topics
- Animals
- Bradykinin
- Cell Proliferation
- Cells, Cultured
- Enzyme Inhibitors
- ErbB Receptors
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Muscle, Smooth, Vascular
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Protein Serine-Threonine Kinases