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Article

Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells.

The Journal of biological chemistry - 7 Sept 2001

Reusch H P, Zimmermann S, Schaefer M, Paul M, Moelling K

Abstract excerpt

The stimulation of platelet-derived growth factor (PDGF) receptors shifts vascular smooth muscle (VSM) cells toward a more proliferative phenotype. Thrombin activates the same signaling cascades in VSM cells, namely the Ras/Raf/MEK/ERK and the phosphatidylinositol 3-kinase (PI 3-kinase)/Akt pathways. Nonetheless, thrombin was not mitogenic, but rather increased the expression of the smooth muscle-specific myosin...

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Identifiers

PMID: 11443134
DOI: 10.1074/jbc.M105322200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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