Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PKC-delta and CaMKII-delta 2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle.

American journal of physiology. Cell physiology - 1 Jun 2004

Ginnan Roman, Pfleiderer Paul J, Pumiglia Kevin, Singer Harold A

Abstract excerpt

ATP, a purinergic receptor agonist, has been shown to be involved in vascular smooth muscle (VSM) cell DNA synthesis and cell proliferation during embryonic and postnatal development, after injury, and in atherosclerosis. One mechanism that ATP utilizes to regulate cellular function is through activation of ERK1/2. In the present study, we provide evidence that ATP-dependent activation of ERK1/2 in VSM cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinase Type 2
Share to Calcium-Calmodulin-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Growth Substances

Share to Mitogen-Activated Protein Kinase 3

Share to Muscle Contraction

Share to Protein Kinase C

Share to Protein Kinase C-delta

Share to src-Family Kinases

Source

Identifiers

PMID: 14749212
DOI: 10.1152/ajpcell.00202.2003

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PKC-delta and CaMKII-delta 2 mediate ATP-dependent activation of ERK1/2 in vascular smooth muscle.PMID 14749212Read ↗

Dual role of PKA in phenotypic modulation of vascular smooth muscle cells by extracellular ATP.Semantic proximity Read ↗

Protein kinase C isoform expression and ATP response change with smooth muscle cell differentiation.Semantic proximity Read ↗

Molecular biology of protein kinase C signaling in cardiac myocytes.Semantic proximity Read ↗

Basal ATP release signals through the P2Y2 receptor to maintain the differentiated phenotype of vascular smooth muscle cells.Semantic proximity Read ↗

Modulation of vascular smooth muscle cell migration by calcium/ calmodulin-dependent protein kinase II-delta 2.Semantic proximity Read ↗

Extracellular ATP: a central player in the regulation of vascular smooth muscle phenotype. Focus on "Dual role of PKA in phenotype modulation of vascular smooth muscle cells by extracellular ATP".Semantic proximity Read ↗

Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes.Semantic proximity Read ↗

Inhibition of MEK/ERK1/2 signalling alters endothelial nitric oxide synthase activity in an agonist-dependent manner.Semantic proximity Read ↗

A potential role for protein kinase C-epsilon in regulating megakaryocytic lineage commitment.Semantic proximity Read ↗

Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-alpha.Semantic proximity Read ↗

Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.Semantic proximity Read ↗

Activation of focal adhesion kinase by protein kinase C epsilon in neonatal rat ventricular myocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.