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Article

The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.

Journal of the American Society of Nephrology : JASN - 1 Jun 2003

Shimamura Haruko, Terada Yoshio, Okado Tomokazu, Tanaka Hiroyuki, Inoshita Seiji, Sasaki Sei

Abstract excerpt

While the serine/threonine protein kinase Akt has attracted attention as a mediator of survival (anti-apoptotic) signal, the regulation and function of the PI3-kinase-Akt pathway in mesangial cells is not well known. To explore the significance of the PI3-kinase-Akt pathway, this study used PI3-kinase inhibitors (Wortmannin and LY294002) and recombinant adenoviruses encoding a dominant-active mutant of Akt...

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Identifiers

PMID: 12761242
DOI: 10.1097/01.asn.0000066140.99610.32

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad.PMID 12761242Read ↗

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