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Article

Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen.

The Journal of biological chemistry - 24 Jan 2003

Haynes M Page, Li Lei, Sinha Diviya, Russell Kerry S, Hisamoto Koji, Baron Roland, Collinge Mark, Sessa William C, Bender Jeffrey R

Abstract excerpt

17beta-Estradiol activates endothelial nitric oxide synthase (eNOS), enhancing nitric oxide (NO) release from endothelial cells via the phosphatidylinositol 3-kinase (PI3-kinase)/Akt pathway. The upstream regulators of this pathway are unknown. We now demonstrate that 17beta-estradiol rapidly activates eNOS through Src kinase in human endothelial cells. The Src family kinase specific-inhibitor...

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Identifiers

PMID: 12431978
DOI: 10.1074/jbc.M210828200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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