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Article

Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation.

Hypertension (Dallas, Tex. : 1979) - 1 Apr 2003

Dugourd Céline, Gervais Marianne, Corvol Pierre, Monnot Catherine

Abstract excerpt

Different signal transduction cascades have been implicated in angiotensin II (Ang II)-mediated cell growth, such as the extracellular signal-regulated kinase 1/2 (ERK1/2) and the phosphatidylinositol 3-kinase (PI3K) pathways. To identify the downstream targets of PI3K involved in Ang II-induced proliferation, we used both rat aortic smooth muscle (RASM) cells and a CHO cell line stably expressing the rat AT1A...

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Identifiers

PMID: 12623864
DOI: 10.1161/01.HYP.0000060821.62417.35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Akt is a major downstream target of PI3-kinase involved in angiotensin II-induced proliferation.PMID 12623864Read ↗

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