Article
Reduced requirement of mitogen-activated protein kinase (MAPK) activity for entry into the S phase of the cell cycle in Swiss 3T3 fibroblasts stimulated by bombesin and insulin.
The Journal of biological chemistry - 30 Aug 1996
Seufferlein T, Withers D J, Rozengurt E
Abstract excerpt
Bombesin induced a marked and persistent activation of the mitogen-activated protein kinase kinase-1 (MEK-1), p42(mapk) and p90(rsk) in Swiss 3T3 cells by a pathway that was independent of p74(raf-1) but dependent on the activity of protein kinase C. Pretreatment of the cells with a specific inhi...
Topics
- 3T3 Cells
- Animals
- Bombesin
- Calcium-Calmodulin-Dependent Protein Kinases
- DNA Replication
- Enzyme Activation
- Fibroblasts
- Insulin
- MAP Kinase Kinase 1
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Protein Kinase C
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Ribosomal Protein S6 Kinases
- S Phase