Article
PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.
Molecular and cellular biology - 1 Dec 2004
Munarriz Eliana, Barcaroli Daniela, Stephanou Anastasis, Townsend Paul A, Maisse Carine, Terrinoni Alessandro, Neale Michael H, Martin Seamus J, Latchman David S, Knight Richard A, Melino Gerry, De Laurenzi Vincenzo
Abstract excerpt
p73 is a recently described member of the p53 family, and, like p53, it undergoes a number of posttranslational modifications. Here we show, by yeast two-hybrid screening, pull-down assays, and coimmunoprecipitation, that p73alpha, -beta, and -gamma bind to the protein inhibitor of activated STAT-1 (PIAS-1) and that this binding stabilizes p73. PIAS-1 also sumoylates p73alpha, although not the C-terminally...
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