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Article

Api5 Contributes to E2F1 Control of the G1/S Cell Cycle Phase Transition

7 Aug 2013

Abstract excerpt

BACKGROUND: The E2f transcription factor family has a pivotal role in controlling the cell fate in general, and in particular cancer development, by regulating the expression of several genes required for S phase entry and progression through the cell cycle. It has become clear that the transcriptional activation of at least one member of the family, E2F1, can also induce apoptosis. An appropriate balance of...

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PMID: 23940755
DOI: 10.1371/journal.pone.0071443

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