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Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage

1 Jun 1995

Abstract excerpt

The human tumour suppressor protein p53 is critical for regulation of the cell cycle on genotoxic insult. When DNA is damaged by radiation, chemicals or viral infection, cells respond rapidly by arresting the cell cycle. A G1 arrest requires the activity of wild-type p53, as it is not observed in cells lacking functionally wild-type protein, and at least some component of S phase and G2/M arrests is also thought...

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PMID: 7575491
DOI: 10.1002/bies.950170606

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