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Article

SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function

1 May 2013

Abstract excerpt

The Pin1 prolyl isomerase regulates phosphorylation signaling by controlling protein conformation after phosphorylation, and its upregulation promotes oncogenesis via acting on numerous oncogenic molecules. SUMOylation and deSUMOylation are dynamic mechanisms regulating a spectrum of protein activities. The SUMO proteases (SENP) remove SUMO conjugate from proteins, and their expression is deregulated in cancers....

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PMID: 23633483
DOI: 10.1158/0008-5472.can-12-4360

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